Free Shipping On Orders Over $99 | £99 | €99

Orders Dispatched Same Day

Your cart

Your cart is empty

Continue shopping

Science And Research

What's The Best Nootropic Stack?

Written by Dr.Marcus 

Published on September 15, 2025

The Optimal Nootropic Stack: Our Top Ingredients for Synergistic Brain Performance

It’s hard to choose from so many nootropics. What do you want from your nootropic usage? Which one should you go for?


Well, realistically, there won’t be any one ingredient that you should go for, as most ingredients are highly specialised, whilst you will want to hit many bases. You will want more than one thing from your nootropics. Also, the effects of any individual nootropic ingredient may well be so mild as to be nearly imperceptible.


This all brings us rather neatly to our own, custom-built nootropic ‘stack’. A stack is a mixture of different nootropic compounds (seventeen, in this case) which, all told, should represent a potent and well-rounded dose of brain boosting effects. These ingredients all work synergistically, meaning that they complement one another well and, in some cases, aid the efficacy of one or more other ingredients in the stack. They are balanced, evidence-based, and should give you something like a high-functioning baseline as you look to support your cognitive abilities and longevity, and your mental clarity and wellbeing.

Motivation and energy

Any good nootropic stack will need to take energy and motivation seriously – optimising these will go a long way towards bolstering your productivity, as well as your overall life quality.


We can do this with a few well-placed, decent ingredients. This starts with Acetyl-L-carnitine, which has been shown to improve cognition in older adults while reducing mental fatigue. Then we will take some N-Acetyl L-Tyrosine (NALT), which gives you a highly bioavailable form of tyrosine. Tyrosine is a precursor to dopamine and norepinephrine, meaning higher levels of each, meaning, in the end, improved mental performance and, often, greater happiness.


Pyrroloquinoline Quinone (PQQ) will go into this stack, too. It’s a redox cofactor that promotes mitochondrial biogenesis and enhances cellular energy efficiency, especially under oxidative stress.

Learning and memory support

A good nootropic stack will have to take learning and memory support into account.
Realistically, this means starting with a good dose of citicoline (CDP-Choline), which will give us the essential building blocks for acetylcholine. Acetylcholine is a neurotransmitter closely linked to memory. Choline is also important for phospholipid repair in neuronal membranes.
Bacopa monnieri is always a good one, too. The benefits on offer – improved memory retention and processing speed, among others – have been roundly backed by modern research. It should allow for benefits in just a few weeks of use.


I would rarely consider a nootropic stack complete without Lion’s Mane mushroom. It’s almost unparalleled ability to stimulate nerve growth factor (NGF) makes it pretty much an auto include. You will see direct benefits to neurogenesis and synaptic plasticity, which will help to ringfence your longer term brain health, supporting your ability to learn and retain and recall memories as you age.


I would also put phosphatidylserine in here, too. It’s a structural phospholipid found in high concentrations in brain cell membranes, and bolstering volume should enhance what you’re getting from the other ingredients in this section – citicoline, Bacopa monnieri, and Lion’s Mane Mushroom – by helping to maintain neuronal communication in the long run whilst also helping memory recall in the moment.

Ageing

No cognitive stack is complete without something to help address ageing. Pine bark extract is a good one, here. It’s rich in proanthocyanidins and has been shown to improve cerebral blood flow whilst also reducing oxidative stress. Benefits have been shown both in the fight against ageing the reversal of the ageing process, and in helping those suffering with ADHD to better manage their symptoms.


Zeaxanthin and lutein, two carotenoids, play a solid role here, too. They are commonly associated with eye health, but also accumulate in the brain, where they help to reduce inflammation whilst also supporting processing speed and memory, especially in older populations.

Mood and stress resilience

Mood and stress resilience are also very important for any decent, holistic nootropic stack. Rhodiola is a good one, here, as an incredibly fast-acting, potent adaptogen. It will improve performance under stress and undercut unhealthy cortisol levels. Saffron works nicely, too. Derived from the Crocus sativus flower, it has mild antidepressant effects comparable to pharmaceutical treatments, most likely because of its influence on serotonin and antioxidant pathways.


L-theanine, meanwhile, smooths out other compounds’ benefits. An amino acid found in green tea, it should promote alpha brain wave activity, offer calm alertness, and overall will help to buffer against any overstimulation from the broader stack as a whole.

Repair and neurotransmitter synthesis

Finally, we need to include a couple of ingredients to keep your brain structurally sound – this means a few things for cellular repair and neurotransmitter synthesis.


Vitamin B6 (as pyridoxal 5-phosphate) is your best bet. It will help to convert amino acids into dopamine, serotonin, and GABA, in which those suffering with mood disorders are often deficient.


Add methylated folate (5-MTHF) and vitamin B12 (as methylcobalamin) to this, as together they will help to support methylation, homocysteine regulation, and neuroprotection. As you might imagine, all of these are important for mood balance and long term brain health.
Finally, we’ll round out this list with phosphatidylcholine. It gives us another crucial phospholipid for neuronal repair and acetylcholine synthesis.

The Most Scientifically Backed Nootropic Supplement - ThinkEase

ThinkEase is a powerful brain-boosting supplement designed to help you think clearly, focus better and remember more.

ORDER THINKEASE

1. ThinkEase Enables Laser Sharp Focus

Stay on task without feeling wired. Citicoline helps raise acetylcholine, the neurotransmitter that drives attention and mental effort. N-acetyl L-tyrosine feeds dopamine synthesis, which supports drive when you face pressure. Rhodiola helps curb stress-related lapses so you can lock in for longer. L-theanine smooths mental noise and reduces distractibility. Pine bark extract supports healthy blood flow to the brain so oxygen and nutrients reach active areas quickly. Acetyl-L-carnitine helps neurons make energy efficiently. Together, these ingredients help you settle into deep, steady focus that lasts through demanding work or study.

2. ThinkEase Improves Mental Clarity

Think clearly even when the day gets busy. L-theanine promotes a calm, settled brain state so thoughts feel tidy rather than scattered. Rhodiola helps tame stress and fatigue that cloud your thinking. Citicoline supports fast membrane signaling, which helps your brain switch between tasks cleanly. Pine bark extract delivers antioxidants that protect against oxidative “static.” Acetyl-L-carnitine and PQQ support mitochondrial energy, the fuel behind crisp mental processing. Vitamin B6, folate, and B12 back healthy neurotransmitter metabolism. The result is a clean, composed kind of alertness that makes decisions feel simpler.

3. ThinkEase Supports Memory

Remember more and recall faster. Bacopa monnieri is well known for supporting memory consolidation over time. Phosphatidylserine helps cell membranes transmit signals involved in forming and retrieving memories. Citicoline supplies choline and supports phospholipid renewal, both important for memory circuits. Lion’s Mane provides natural compounds that support nerve growth factor, which is linked with neuroplasticity. Pine bark extract supports circulation and protects neurons, while B vitamins help maintain healthy homocysteine levels related to cognitive aging. Together, these ingredients help short-term recall and long-term retention feel more reliable.

4. ThinkEase Accelerates Learning

Make new information stick. Citicoline supports acetylcholine activity for learning efficiency. Bacopa helps with information encoding during study cycles. Lion’s Mane supports neural growth and plasticity, which your brain uses to build new connections. Phosphatidylserine supports healthy signaling at synapses so new pathways form and strengthen. Acetyl-L-carnitine provides clean cellular energy during intense mental work. Lutein and zeaxanthin concentrate in brain tissue and are linked with processing speed and visual learning. With these compounds working together, practice sessions feel more productive and progress shows up sooner.

5. ThinkEase Improves Reasoning Skills

Think through problems with composure. N-acetyl L-tyrosine supports dopamine during stress, which helps flexible thinking and working memory under pressure. Rhodiola reduces mental fatigue so you can hold complex ideas in mind. Phosphatidylserine supports executive function by keeping cell signaling sharp. Citicoline and pine bark extract support blood flow and membrane renewal so networks communicate smoothly. Acetyl-L-carnitine and PQQ back mitochondrial output for sustained mental calculation. L-theanine encourages calm concentration so reasoning feels deliberate and balanced, not rushed.

6. ThinkEase Ignites Productivity

Get more done in less time. Tyrosine supports motivation and task initiation. Rhodiola helps you resist dips in energy through long afternoons. Citicoline and phosphatidylserine keep cognitive gears turning so you move from planning to action without friction. L-theanine promotes a calm work rhythm that reduces multitasking and mind wandering. B6, folate, and B12 support neurotransmitter pathways for steady mental stamina. Acetyl-L-carnitine and PQQ aid cellular energy so output stays consistent. The net effect is smooth momentum from first task to last.

7. ThinkEase Protects Brain Health

Protect the foundations of long-term cognitive health. Lion’s Mane supports neurotrophic factors involved in the maintenance of healthy neurons. Phosphatidylserine and citicoline help rebuild cell membranes and keep them signaling well. PQQ and pine bark extract provide antioxidant support and help protect mitochondria, the power centers of brain cells. Lutein and zeaxanthin are brain-active carotenoids linked with healthy cognition across the lifespan. B6, folate, and B12 support methylation and homocysteine balance. Together with acetyl-L-carnitine for cellular energy, ThinkEase supports a resilient, well-nourished brain.

A Formula You Can Trust

Safety and quality come first. ThinkEase is manufactured in the USA in an FDA-registered, cGMP-compliant facility, with full lot traceability from raw materials to finished bottles. Every batch is third-party tested by independent, ISO-accredited labs for identity, purity, and potency. We screen for heavy metals (lead, arsenic, cadmium, mercury), microbials, and other contaminants, and we verify that each active meets its label claim. Certificates of Analysis are available for every lot, and products are stored and shipped under controlled conditions to protect freshness and efficacy.

ORDER THINKEASE

References

  1. Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR in Biomedicine. 2008;21(10):1066–1075. https://doi.org/10.1002/nbm.1280 gavinpublishers.com
  2. Grieb P. Citicoline and brain health: mechanisms and clinical evidence. Nutrients. 2014;6(12):5451–5474. https://doi.org/10.3390/nu6125451 PMC
  3. Pase MP, Kean J, Sarris J, Neale C, Scholey AB, Stough C. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Journal of Ethnopharmacology. 2012;141(3):793–801. https://doi.org/10.1016/j.jep.2012.09.002 Keio University
  4. Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Journal of Alternative and Complementary Medicine. 2008;14(6):707–713. https://doi.org/10.1089/acm.2007.0286 Research Features
  5. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Hericium erinaceus on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research. 2009;23(3):367–372. https://doi.org/10.1002/ptr.2634 Semantic Scholar
  6. Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015;31(6):781–786. https://doi.org/10.1016/j.nut.2014.10.014
  7. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dementia and Geriatric Cognitive Disorders. 2011;31(6):423–429. https://doi.org/10.1159/000330806
  8. Trebatická J, Kopasová S, Hradečná Z, et al. Treatment of ADHD with French maritime pine bark extract (Pycnogenol®). European Child & Adolescent Psychiatry. 2006;15(6):329–335. https://doi.org/10.1007/s00787-006-0538-3
  9. Dvořáková M, Šimůnek J, Skopková J, et al. The effect of polyphenolic extract from pine bark (Pycnogenol®) on the level of 8-oxoguanine in children suffering from ADHD. Redox Report. 2006;11(4):163–172. https://doi.org/10.1179/135100006X116664
  10. Renzi-Hammond LM, Bovier ER, Fletcher LM, Miller LS, Mewborn CM, Lindbergh CA, Baxter J, Hammond BR Jr. A randomized, double-masked, placebo-controlled trial of lutein and zeaxanthin supplementation on cognitive function in young healthy adults. Nutrients. 2017;9(11):1246. https://doi.org/10.3390/nu9111246
  11. Power R, Coen RF, Beatty S, et al. Supplemental retinal carotenoids enhance memory in healthy individuals with low levels of macular pigment in a randomized, double-blind, placebo-controlled clinical trial. Journal of Alzheimer’s Disease. 2018;61(3):1–13. https://doi.org/10.3233/JAD-170713
  12. Lindbergh CA, Mewborn CM, Hammond BR Jr, Curran-Celentano J, Miller LS. Lutein and zeaxanthin influence brain function in older adults: a randomized controlled trial. Journal of the International Neuropsychological Society. 2018;24(1):77–90. https://doi.org/10.1017/S1355617717000534
  13. Olsson EMG, von Schéele B, Panossian AG. A randomized, double-blind, placebo-controlled, parallel-group study of the standardized extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Medica. 2009;75(2):105–112. https://doi.org/10.1055/s-0028-1088346
  14. Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003;10(2–3):95–105. (doi shown on publisher page)
  15. Hausenblas HA, Saha D, Dubyak PJ, Anton SD. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. Journal of Integrative Medicine. 2013;11(6):377–383. https://doi.org/10.3736/jintegrmed2013056
  16. Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi A-H, Khalighi-Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial. BMC Complementary and Alternative Medicine. 2004;4:12. https://doi.org/10.1186/1472-6882-4-12
  17. Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB. The effects of L-theanine, caffeine and their combination on cognition and mood. Psychopharmacology (Berl). 2008;199(3): 1–9. https://doi.org/10.1007/s00213-008-1106-9
  18. Allen GFG, Neergheen V, Oppenheim M, et al. Pyridoxal 5′-phosphate deficiency causes loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells: implications for vitamin B6 deficiency states. Journal of Neurochemistry. 2010;114(1):87–96. https://doi.org/10.1111/j.1471-4159.2010.06742.x
  19. Smith AD, Smith SM, de Jager CA, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE. 2010;5(9):e12244. https://doi.org/10.1371/journal.pone.0012244
  20. Durga J, van Boxtel MPJ, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomized, double-blind, controlled trial. The Lancet. 2007;369(9557):208–216. https://doi.org/10.1016/S0140-6736(07)60109-3
  21. Zhang J, Wang Y, Wang X, et al. L-carnitine ameliorated fasting-induced fatigue, hunger, and cognitive function. Nutrition Journal. 2014;13:110. https://doi.org/10.1186/1475-2891-13-110
  22. Nakano M, Ariyasu T, Matoba M, Enoki T. Randomized double-blind placebo-controlled trial of PQQ disodium salt in adults: effects on psychophysiological fatigue, sleep quality and lipid metabolism. Food & Function. 2023;14(6):2770–2781. https://doi.org/10.1039/D2FO01515C Semantic Scholar
  23. Young SN. L-tyrosine to alleviate the effects of stress? Amino Acids. 2007;33(1):63–68. https://doi.org/10.1007/s00726-007-0510-5
  24. Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annual Review of Nutrition. 2009;29:261–282. https://doi.org/10.1146/annurev.nutr.29.061307.155515

The High Dose Premium Nootropic Supplement

  • Laser Sharp Focus

  • Crystal Clear Clarity

  • Boost Memory Recall

  • Accelerate Learning

  • Improve Reasoning

  • Ignite Productivity

  • Protect Brain Health

ORDER THINKEASE

✔️ 60-Day Money-Back Guarantee

ORDER THINKEASE